منابع مشابه
Recognition of a TG Mismatch The Crystal Structure of Very Short Patch Repair Endonuclease in Complex with a DNA Duplex
The crystal structure of very short patch repair (Vsr) endonuclease, in complex with Mg2+ and with duplex DNA containing a TG mismatch, has been determined at 2.3 A resolution. In E. coli, the enzyme recognizes a TG mismatched base pair, generated after spontaneous deamination of methylated cytosines, and cleaves the phosphate backbone on the 5' side of the thymine. Extensive interactions betwe...
متن کامل(CA/TG) microsatellite sequences escape the inhibition of recombination by mismatch repair in Saccharomyces cerevisiae.
Sequence divergence reduces the frequency of recombination, a process that is dependent on the activity of the mismatch repair system. In the yeast Saccharomyces cerevisiae, repair of mismatches results in gene conversion or restoration, whereas failure to repair mismatches results in postmeiotic segregation (PMS). By examining the conversion and PMS in yeast strains deficient in various MMR ge...
متن کاملCrystal Structure of a G:T/U Mismatch-Specific DNA Glycosylase Mismatch Recognition by Complementary-Strand Interactions
G:U mismatches resulting from deamination of cytosine are the most common promutagenic lesions occurring in DNA. Uracil is removed in a base-excision repair pathway by uracil DNA-glycosylase (UDG), which excises uracil from both single- and double-stranded DNA. Recently, a biochemically distinct family of DNA repair enzymes has been identified, which excises both uracil and thymine, but only fr...
متن کاملBandwidth mismatch compensation for robust speech recognition
In this paper, an iterative bandwidth mismatch compensation (BMC) algorithm is proposed to alleviate the need of multiple pre-trained models for recognizing different bandwidth speech. The BMC uses the concept of the bandwidth extension as similar as in the speech enhancement approaches. However, it aims at directly improving the recognition accuracy instead of speech intelligence or quality an...
متن کاملTG-21 versus TG-25: a comparison for electrons.
Since 1984, the Radiological Physics Center (RPC) has used the American Association of Physicists in Medicine Task Group 21 (TG-21) protocol (absorbed dose determination) as the basis of its On-site Dosimetry Review visits to institutions participating in the National Cancer Institute's cooperative clinical trials. Subsequent to the TG-21 protocol, the Task Group 25 (TG-25) report on electron-b...
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ژورنال
عنوان ژورنال: Cell
سال: 1999
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)81550-0